1144084-91-2Relevant academic research and scientific papers
A General Method for α-Oxyacylation of Vinyl Ketones Using Koser's Reagent
Azaz, Tazeen,Mishra, Bal Krishna,Mourya, Hemlata,Pandey, Chandra Bhan,Ram, Bali,Tiwari, Bhoopendra
, p. 17318 - 17327 (2021/12/02)
A direct general method for the preparation of α-oxyacylated vinyl ketones using Koser's hypervalent iodine reagent is reported. A variety of acyloxy groups from long-chain aliphatic, aromatic, α,β-unsaturated carboxylic acids have been installed efficiently for the first time. The oxyacylated adducts were used for the preparation of densely functionalized chiral δ-lactones and cyclopentenes using carbene organocatalysis.
Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor
Dong, Suwei,Hamel, Ernest,Bai, Ruoli,Covell, David G.,Beutler, John A.,Porco Jr., John A.
supporting information; experimental part, p. 1494 - 1497 (2009/07/25)
A bicycle built for tubulin: The Total synthesis of (+)- chamaecypanone C has been achieved by using a tandem retro-Diels-Alder cascade reaction (see scheme). Initial biological studies demonstrate that (+)- chamaecypanone C is an inhibitor of tubulin assembly and binds at the colchicine site.
