1144085-01-7Relevant academic research and scientific papers
Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor
Dong, Suwei,Hamel, Ernest,Bai, Ruoli,Covell, David G.,Beutler, John A.,Porco Jr., John A.
, p. 1494 - 1497 (2009)
A bicycle built for tubulin: The Total synthesis of (+)- chamaecypanone C has been achieved by using a tandem retro-Diels-Alder cascade reaction (see scheme). Initial biological studies demonstrate that (+)- chamaecypanone C is an inhibitor of tubulin assembly and binds at the colchicine site.
