1144100-40-2Relevant academic research and scientific papers
Benzimidazole-1,2,3-triazole hybrid molecules: Synthesis and evaluation for antibacterial/antifungal activity
Ouahrouch, Abdelaaziz,Ighachane, Hana,Taourirte, Moha,Engels, Joachim W.,Sedra, My Hassan,Lazrek, Hassan B.
, p. 748 - 755 (2014)
A novel series of hybrid molecules 4a-i and 5a-i were prepared by condensation of 4-(trimethylsilylethynyl)benzaldehyde 1 with substituted o-phenylenediamines. These in turn were reacted with 2-(azidomethoxy)ethyl acetate in a Cu alkyne-azide cycloaddition (CuAAC) to generate the 1,2,3-triazole pharmacophore under microwave assistance. The newly synthesized compounds were examined for their in vitro antimicrobial activities against Gram-positive and Gram-negative bacteria and the phytopathogenic fungi Verticillium dahliae and Fusarium oxysporum f. sp. albedinis. 2-((4-(4-(5-Trifluoromethyl benzimidazol-2-yl)phenyl)-1,2,3-triazol-1-yl)methoxy)ethanol 5e showed a moderate inhibition of 30% in the Foa sporulation test. Hybrid molecules including benzimidazole, benzene, and triazole rings were synthesized and characterized. The compounds were assessed for their in vitro antimicrobial activities against Gram-positive and Gram-negative bacteria and phytopathogenic fungi. 2-((4-(4-(5-Trifluoromethyl benzimidazol-2-yl)phenyl)-1,2,3-triazol-1-yl)-methoxy)ethanol 5e was found to achieve moderate inhibition of 30% in the Foa sporulation test.
Additive- and Oxidant-Free Expedient Synthesis of Benzimidazoles Catalyzed by Cobalt Nanocomposites on N-Doped Carbon
Wang, Zhaozhan,Song, Tao,Yang, Yong
supporting information, p. 319 - 324 (2019/02/12)
A one-pot direct synthesis of a wide range of biologically active benzimidazoles through coupling of phenylenediamines and aldehydes catalyzed by a highly recyclable nonnoble cobalt nanocomposite was developed. A broad set of benzimidazoles can be efficiently synthesized in high yields and with good functional-group tolerance under additive- and oxidant-free mild conditions. The catalyst can be easily recycled for successive uses, and the process permits gram-scale syntheses of benzimidazoles.
Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents
Hu, Laixing,Kully, Maureen L.,Boykin, David W.,Abood, Norman
scheme or table, p. 1292 - 1295 (2009/10/15)
A new class of novel bis-benzimidazole diamidine compounds have been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Anti-MRSA and anti-VRE activities of the most potent compound 1 were more act
