114420-45-0

Basic information

• Product Name: Piperazine, 2,5-bis(1-methylethyl)-, trans- (9CI)
• Synonyms: Piperazine, 2,5-bis(1-methylethyl)-, trans- (9CI);(2R,5S)-2,5-BIS(1-METHYLETHYL)PIPERAZINE
• CAS NO: 114420-45-0
• Molecular Formula: C10H22N2
• Molecular Weight: 170.29508
• Product Categories: PIPERIDINE
• Mol File: 114420-45-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 238.3±8.0 °C(Predicted)
• Appearance: /
• Density: 0.839±0.06 g/cm3(Predicted)
• PKA: 9.45±0.60(Predicted)
• CAS DataBase Reference: Piperazine, 2,5-bis(1-methylethyl)-, trans- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 2,5-bis(1-methylethyl)-, trans- (9CI)(114420-45-0)
• EPA Substance Registry System: Piperazine, 2,5-bis(1-methylethyl)-, trans- (9CI)(114420-45-0)

Safety Data

• Hazardous Substances Data: 114420-45-0(Hazardous Substances Data)

Upstream product

• 24294-83-5 2,5-bis(1-methylethyl)pyrazine 
• 19943-14-7 3,6-diisopropyl-piperazine-2,5-dione 
• 19943-16-9 (3S,6S)-3,6-bis(isopropyl)piperazine-2,5-dione 
• 6306-52-1 L-valine methylester hydrochloride 
• 72-18-4 L-valine 
• 62596-65-0 (2S)-2-isopropyl-1-[(4-methylphenyl)sulfonyl]aziridine 
• 139192-48-6 (S)-N-(1-hydroxy-3-methylbutan-2-yl)-4-methylbenzenesulfonamide 
• 51220-85-0 Methyl (S)-N-<(4-methylphenyl)sulfonyl>valinate 

Relevant articles and documents

Asymmetric Synthesis Using Chiral Piperazine. I. Asymmetric Synthesis of 2-Substituted Alcohol and Carboxylic Acid by Diastereoselective Alkylation of Chiral Diamides Derived from Piperazines

The diastereoselective alkylation of chiral diamides derived from chiral piperazines afforded optically active alcohols and acids in moderate enantiomeric excesses (up to 68percent e.e.).

An efficient synthetic approach for N-C bond formation from (S)-amino acids: An easy access to cis-2,5-disubstituted chiral piperazines

An efficient synthetic strategy is described for the construction of amino acids derived enantiomerically pure cis-2,5-disubstituted chiral piperazines. Cu-catalyzed spontaneous regioselective ring opening and ring closing of non-activated N-tosyl aziridines as well as Pd-mediated N-C bond formation from N-tosyl halogenated amino-derivatives are the key steps for accessing disubstituted piperazines.

Sodium borohydride-boron trifluoride ethereate, a convenient and efficient reagent for the reduction of amides

Sodium borohydride-boron trifluoride ethereate has been employed as a reducing agent for the conversion of amides into amines, the reducing species being diborane generated in situ.This method successfully reduces primary, secondary and tertiary amides, lactams and chiral diketopiperazines, in moderate to high yields.An unusual ring cleavage is observed in the reduction of the pyrroloquinazolin-1-one (7a) resulting in the formation of benz-1,6-diazonine (7b).