114432-66-5

Basic information

• Product Name: 1-Butanamine, N-butyl-N-[3-[4-[[2-(1,1-dimethylethyl)-1-indolizinyl]sulfonyl]phenoxy]prop yl]-
• CAS NO: 114432-66-5
• Molecular Formula: C29H42N2O3S
• Molecular Weight: 498.73
• Mol File: 114432-66-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-Butanamine, N-butyl-N-[3-[4-[[2-(1,1-dimethylethyl)-1-indolizinyl]sulfonyl]phenoxy]prop yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanamine, N-butyl-N-[3-[4-[[2-(1,1-dimethylethyl)-1-indolizinyl]sulfonyl]phenoxy]prop yl]-(114432-66-5)
• EPA Substance Registry System: 1-Butanamine, N-butyl-N-[3-[4-[[2-(1,1-dimethylethyl)-1-indolizinyl]sulfonyl]phenoxy]prop yl]-(114432-66-5)

Safety Data

• Hazardous Substances Data: 114432-66-5(Hazardous Substances Data)

Upstream product

• 114432-30-3 Toluene-4-sulfonic acid 4-(2-tert-butyl-indolizine-1-sulfonyl)-phenyl ester 
• 133804-17-8 5-tosyloxyphenyl 2-methylpyridyl sulfone 
• 4377-33-7 2-chloromethylpyridine 
• 36421-15-5 dibutyl-(3-chloro-propyl)-amine 
• 114432-37-0 2-tert-Butyl-1-(4-hydroxybenzenesulphonyl)indolizine 

Relevant articles and documents

A Novel Class of Calcium-Entry Blockers: The 1-sulfonyl>indolizines

The synthesis and initial biological evaluation of a series of 1-sulfonylindolizines is described.These compounds have been shown to be representatives of a novel class of potent, slow-channel calcium antagonists.All compounds were found to be at least as active as the reference calcium antagonists verapamil and cis-(+)-diltiazem.Structure-activity relationship studies have shown that all compounds possessing an aralkyl group in the amine moiety and an isopropyl or cyclopropyl group at the 2 position of the indolizine are among the most potent calcium antagonists know n outside the 1,4-dihydropyridine series.The IC50 value for the inhibition of nitrendipine binding vary between o.19 and 4.5 nM whereas the IC50 value for nifedipine is 2.5 nM.One of the compounds in this group (9ab) has now been selected for clinical development.