114446-52-5

Basic information

• Product Name: -(-)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane

Upstream product

• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 
• 141987-54-4 1-Phenyl-3-chlor-propyl-monochloracetat 
• 936-59-4 3-chloropropiophenone 
• 90-05-1 2-methoxy-phenol 
• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 

Downstream Products

• 112066-66-7 (S)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine 
• 114446-54-7 -(-)-nisoxetine hydrochloride 

Relevant articles and documents

Chemoenzymatic synthesis of the non-tricyclic antidepressants Fluoxetine, Tomoxetine and Nisoxetine

3-Chloro-1-phenylpropan-1-ol and the corresponding butanoate, 3-chloro-1-phenyl-1-propyl butanoate, were kinetically resolved using lipase B from Candida antarctica catalysis by transesterification and hydrolysis respectively. The resulting chiral building blocks (S)- and (R)-3-chloro-1-phenylpropanol were converted into both enantiomers of the antidepressant drugs, Fluoxetine, Tomoxetine and Nisoxetine. The Royal Society of Chemistry 2000.

An efficient route to enantiomerically pure antidepressants: Tomoxetine, nisoxetine and fluoxetine

Both enantiomers (R)- and (S)-3-chloro-1-phenyl-1-propanol can be obtained conveniently by an efficient enzymatic resolution process. They can be converted via enantioconvergent routes into all enantiomers of the important antidepressants (R)- and (S)-Tomoxetine, Fluoxetine and Nisoxetine.