1144465-46-2Relevant academic research and scientific papers
Synthesis and cytotoxicity studies of thiazole analogs of the anticancer marine alkaloid dendrodoine
Reji, T. F. Abbs Fen,Devi,Thomas,Sreejalekshmi,Manju,Francis,Philip,Bharathan,Rajasekharan
, p. 1145 - 1150 (2008/12/23)
The synthesis and cytotoxicity evaluation of 2-N,N-dimethylamino-5-indol-3- oylthiazole as the first member of a new portfolio of the thiazole analogs of the cytotoxic marine alkaloid dendrodoine (3-N,N-dimethylamino-5-indol-3-oyl-1, 2,4-thiadiazole) is described. Exploiting the opportunity arising from the replacement of the thiadiazole ring of dendrodoine by a thiazole ring which allowed further substitution on the five-membered ring, 2-N,N-dimethylamino-5- indoI-3-oyl-4-phenylthiazole has also been synthesized. Structural diversity is further extended by synthesizing 5-fur-2-oyl- and 5-coumarin-3-oyl-2-N,N- dimethylaminothiazoles, as well as 5-fur-2-oyl, 5-thiophen-2-oyl, 5-(1-methylbenzimidazol-2-oyl) and 5-benzothiazol-2-oyl derivatives of 2-N,N-dimethylamino-4-phenylthiazoles. Among these new N,N- dimethylaminothiazoles, 2-N,N-dimethylamino-5-indol-3-oyl-4-phenylthiazole shows significant in vitro cytotoxicity against a panel of human cancer cell lines.
