1144503-33-2Relevant academic research and scientific papers
A general method for the synthesis of N-unsubstituted 3,4-diarylpyrrole-2, 5-dicarboxylates
Fukuda, Tsutomu,Hayashida, Yukie,Iwao, Masatomo
experimental part, p. 1105 - 1122 (2010/09/16)
A general method for the synthesis of N-unsubstituted 3,4-diarylpyrrole-2, 5-dicarboxylates (3) has been developed. The key reactions involved are the Hinsberg-type synthesis of dimethyl N-benzyl-3,4-dihydroxypyrrole-2,5- dicarboxylate (6) followed by palladium-catalyzed Suzuki-Miyaura coupling of its bis-triflate derivative (7). The N-benzyl protecting group of the resulting 3,4-diaryl pyrrole-2,5-dicarboxyl ates (8) is cleanly removed under hydrogenolytic or solvolytic conditions.
