114460-75-2Relevant academic research and scientific papers
Nucleic acid components and their analogs: Design and synthesis of novel cytosine thioglycoside analogs
Elgemeie, Galal H.,Salah, Ali M.,Abbas, Nermeen S.,Hussein, Hoda A.,Mohamed, Reham A.
, p. 139 - 150 (2017)
The synthesis of a new category of novel cytosine 4-thioglycoside analogs has been first accomplished. The main step of this strategy is the synthesis of sodium pyrimidine-4-thiolate through the condensation of 2-cyano-N-arylacetamides with sodium cyanocarbonimidodithioate, followed by coupling with α-bromo-sugars to afford the corresponding cytosine 4-thioglycoside analogs. The free thioglycosides were also prepared. Subsequent studies on the application of this strategy for the preparation of other potent pyrimidine thioglycosides are reported.
CYCLIZATION REACTION OF NITRILES. 26. SYNTHESIS, STRUCTURE, AND PROPERTIES OF 2-AMINO-4-METHYLTHIO-5-CYANO-6(1H)-PYRIMIDINETHIONE
Sharanin, Yu. A.,Shestopalov, A. M.,Nesterov, V. N.,Litvinov, V. P.,Mortikov, V. Yu.,et. al.
, p. 1105 - 1112 (2007/10/02)
2-Amino-4-methylthio-5-cyano-6(1H)-pyrimidinethione has been prepared via treatment of N-cyanodimethyldithioimidate or 1,1-di(methylthio)-2-thiocarbamoyl-2-cyanoethylene with cyanothioacetamide or cyanamide.The structure of the complex formed between 2-amino-4-methylthio-5-cyano-6(1H)-pyrimidinethione and urea has been studied by x-ray structural analysis.Thienopyrimidines and thiazolopyrimidinium salts have been synthesized based on the 6(1H)-pyrimidinethione.
