114469-27-1Relevant articles and documents
Synthesis of tritium labelled thiorphan, an enkephalinase inhibitor
Wu, Shao-Yong,Masjedizadeh, Mohammad R.
body text, p. 23 - 28 (2009/05/09)
Tritium labelling of the enkephalinase inhibitor, thiorphan, is complicated by the presence of mercapto functional group. Reactions often used in aromatic tritiation, such as halogination and catalytic halogen/tritium displacement, are adversely affected
CYCLOPROPYL-ALANINE ARYL/ALKYLSULFIDE/SULFONYL-TERMINATED AMINO-DIOL COMPOUNDS FOR TREATMENT OF HYPERTENSION
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, (2008/06/13)
Compounds characterized generally as cyclopropyl alanine aryl/alkylsulfide/sulfonyl-terminated amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of the formula STR1 wherein
Synthesis and biological activity of some transition-state inhibitors of human renin
Buhlmayer,Caselli,Fuhrer,Goschke,Rasetti,Rueger,Stanton,Criscione,Wood
, p. 1839 - 1846 (2007/10/02)
A series of renin inhibitors containing the dipeptide transition state mimics (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-7-methyloctanoic acid (Leu-(OH)-Val) and (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-6-cyclohexylhexanoic acid (Cha-(OH)-Val) was prepared.
Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
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, (2008/06/13)
Compounds of the formula STR1 in which R1 represents acyl substituted by a thio, sulphinyl or sulphonyl group, A represents an optionally N-alkylated α-amino acid residue that is bonded N-terminally to R1 and C-terminally to the grou