114469-38-4Relevant academic research and scientific papers
PEPTIDES RETROVIRAL PROTEASE INHIBITORS COMPRISING 2-AMINO-2-METHYLPROPIONIC ACID
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, (2008/06/13)
Antiviral peptides of the formula STR1 in which W is an amino protecting group,A,B,D,E and L each independently is a direct bond, or a radical of the formula STR2 R 1 and R 2 each independently is cycloakyl or optionally substituted alkyl or alkenyl,Y is--NHR 10, andR 10 is cycloalkyl or optionally substituted alkyl, and their physiologically acceptable salts.The formula includes a 2-amino-2-methylpropionic acid (AiB) residue, which may optionally be protected, as the N-terminal α-amino acid. The peptides are expected to be useful as medicaments, in particular as antiviral agents in human and veterinary medicine. The peptides are shown to inhibit aspartyl proteases including human immunodeficiency virus (HIV) protease, to have anti-HIV activity and to inhibit the proliferation of HIV in HIV-I infected human lymphocytes. The peptides are expected to be useful in treating patients having HIV related disorders such as ARC and AIDS.
Synthesis and biological activity of some transition-state inhibitors of human renin
Buhlmayer,Caselli,Fuhrer,Goschke,Rasetti,Rueger,Stanton,Criscione,Wood
, p. 1839 - 1846 (2007/10/02)
A series of renin inhibitors containing the dipeptide transition state mimics (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-7-methyloctanoic acid (Leu-(OH)-Val) and (2S,4S,5S)-5-amino-4-hydroxy-2-isopropyl-6-cyclohexylhexanoic acid (Cha-(OH)-Val) was prepared.
