1144853-71-3Relevant articles and documents
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6
Chu, Wenhua,Rothfuss, Justin,Chu, Yunxiang,Zhou, Dong,Mach, Robert H.
supporting information; experimental part, p. 2188 - 2191 (2010/03/03)
A key step in the onset of Huntington's disease is the caspase-6 mediated cleavage of the protein huntingtin into toxic fragments. Therefore, the inhibition of caspase-6 has been identified as a target for therapeutic drug development for the treatment of
