114489-63-3Relevant academic research and scientific papers
Synthesis and antiviral evaluation of carbocyclic 3′-azidothymidine (AZT) analogues and their cycloSal-phosphate triesters
Ludek, Olaf R.,Balzarini, Jan,Meier, Chris
, p. 932 - 940 (2007/10/03)
Carbocyclic analogues of the anti-HIV dideoxynucleoside 3′-azido-3′-deoxythymidine AZT (1) were synthesized. Starting from the enantiomerically pure carbocyclic 2′-deoxythymidine 2, four different carbocyclic AZT analogues 2,4-6 were prepared. Moreover, t
Synthesis of carbocyclic nucleotides as potential substrates for thymidylate kinase
Ludek,Meier
, p. 683 - 686 (2008/02/03)
Enantiomerically pure carbocyclic 2′-deoxy-3′-azidothymidine monophosphate (AZTMP) and carba-2′deoxy-3′-thiocyanatothymidine monophosphate were synthesized to study their behavior toward their phosphorylation by thymidylate kinase. The nucleotides were sy
Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2'-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one
Beres,Sagi,Tomoskozi,Gruber,Baitz-Gacs,Otvos,De Clercq
, p. 1353 - 1360 (2007/10/02)
Enantiomerically pure (+)- and (-)-carbocyclic thymidine, (-)-carbocyclic 3'-epi-thymidine, (+)-carbocyclic 3'-deoxy-3'-azidothymidine, (+)-carbocyclic 2,3'-O-anhydrothymidine, (+)-carbocyclic 3'-O,6'-methylenethymidine, and (+)-(6'S)-carbocyclic 6'-methy
