114495-05-5Relevant academic research and scientific papers
Long-range inhibitor-induced conformational regulation of human IRE1α endoribonuclease activity
Concha, Nestor O.,Smallwood, Angela,Bonnette, William,Totoritis, Rachel,Zhang, Guofeng,Federowicz, Kelly,Yang, Jingsong,Qi, Hongwei,Chen, Stephanie,Campobasso, Nino,Choudhry, Anthony E.,Shuster, Leanna E.,Evans, Karen A.,Ralph, Jeff,Sweitzer, Sharon,Heerding, Dirk A.,Buser, Carolyn A.,Su, Dai-Shi,DeYoung, M. Phillip
, p. 1011 - 1023 (2015)
Activation of the inositol-requiring enzyme-1 alpha (IRE1α) protein caused by endoplasmic reticulum stress results in the homodimerization of the N-terminal endoplasmic reticulum luminal domains, autophosphorylation of the cytoplasmic kinase domains, and
