1145-24-0

Upstream product

• 1145-23-9 racemic-2,4-diphenylpentane 
• 1222-47-5 1,3-diphenylglutarodinitrile 
• 625-67-2 2,4-dichloropentane 
• 100-58-3 phenylmagnesium bromide 
• 1145-23-9 meso-2,4-diphenylpentane 
• 140-29-4 phenylacetonitrile 
• 59147-59-0 meso-2,4-Diphenylglutarsaeure 
• 20698-77-5 meso-1,5-dihydroxy-2,4-diphenylpentane 

Downstream Products

• 1145-23-9 racemic-2,4-diphenylpentane 
• 1145-23-9 meso-2,4-diphenylpentane 

Relevant academic research and scientific papers

Cross-coupling of non-activated chloroalkanes with aryl grignard reagents in the presence of iron/N-heterocyclic carbene catalysts

An efficient and high-yielding cross-coupling reaction of various primary, secondary, and tertiary alkyl chlorides with aryl Grignard reagents was achieved by using catalytic amounts of N-heterocyclic carbene ligands and iron salts. This reaction is a simple and efficient arylation method having applicability to a wide range of industrially abundant chloroalkanes, including polychloroalkanes, which are challenging substrates under conventional cross-coupling conditions.

PROCESS FOR PRODUCTION OF AROMATIC COMPOUNDS

A problem of the present invention is to provide an economical process with minimized toxicity for producing an aromatic compound having a variety of substituents such as various alkyl groups, and the problem is solved by a process for production of an aromatic compound represented by formula (1) below, which comprises reacting a compound represented by formula (2) below with an aromatic magnesium reagent represented by formula (3a) below in the presence of an iron catalyst and a diamine compound: wherein R is an optionally substituted hydrocarbon group or a C 3 - C 10 saturated or unsaturated ring group; A is an optionally substituted C 4 - C 20 aromatic group or an optionally substituted heteroaromatic group; X is a halogen atom or a sulfonic acid ester; and Y 1 is bromine, iodine, chlorine or a carbanion ligand.