114546-08-6

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 116181-32-9 (-)-N¹-norphysostigmine fumarate 
• 624-83-9 methyl isocyanate 
• 114546-59-7 (-)-N¹-phenethylnoreseroline 
• 114546-56-4 (-)-N¹-phenethylnoreseromethole 
• 64-04-0 phenethylamine 

Relevant academic research and scientific papers

Design, synthesis and evaluation of carbamate-modified (-)-N1-phenethylnorphysostigmine derivatives as selective butyrylcholinesterase inhibitors

We synthesized carbamate-modified (-)-N1-phenethylnorphysostigmine derivatives 3a-u and evaluated their anti-cholinesterase activities. In vitro evaluation showed that cyclohexylmethylcarbamate derivative 3u potently and selectively inhibits bu

Preparation and Selective Inhibition of Human Butyrylcholinesterase by N1-Phenethylnorphysostigmine Analogues

N1-Phenethylnorphysostigmine (13) and 3 arylcarbamate analogues (14-16) were prepared by a novel route. These compounds are less active inhibitors of human acetylcholinesterase (AChE) but more potent and selective inhibitors of human butyrylcho

Synthesis and Anticholinesterase Activity of (-)-N1-Norphysostigmine, (-)-Eseramine, and Other N(1)-Substituted Analogues of (-)-Physostigmine

(-)-N1-Benzylnorphysostigmine (4), prepared from synthetic (-)-O-methyl-N1-noreseroline (1) by N-benzylation, ether cleavage, and reaction of (-)-N1-benzylnoreseroline (3) with methyl isocyanate, was the intermediate used to prepare the title compounds.Catalytic debenzylation of (4) afforded (-)-N1-norphysostigmine (5), and (-)-eseramine (6) was obtained by reaction of 5 with methyl isocyanate.Reductive N-methylation of 5 gave (-)-physostigmine (9) while reaction of 5 with allyl bromide and phenethyl bromide afforded carbamates 7 and 8, respectively.Data on the in vitro potencies (IC50) and activities of certain of these compounds (4-8) as inhibitors of electric eel acetyl cholinesterase are reported. (-)-N1-Norphysostigmine (5) was found to be similarly potent against AChE as (-)-physostigmine (9).