114552-61-3Relevant academic research and scientific papers
Direct one-pot synthesis of zolimidine pharmaceutical drug and imidazo[1,2-a]pyridine derivatives via I2/CuO-promoted tandem strategy
Cai, Qun,Liu, Mei-Cai,Mao, Bi-Ming,Xie, Xuan,Jia, Feng-Cheng,Zhu, Yan-Ping,Wu, An-Xin
, p. 881 - 884 (2015/03/04)
An efficient one-pot synthetic protocol was developed for the synthesis of imidazo[1,2-a]pyridines from easily available starting materials: Aromatic ketones, α,β-unsaturated ketones, β-keto esters and 2-aminopyridines. The present reaction proceeded well in MeOH under the media of I2/CuO. By using this method, the marketed drug zolimidine could be prepared easily with 95% yield. All these target products were characterized by NMR, HRMS and IR spectra. Furthermore, the target compound 3fa was determined by X-ray crystallographic analysis.
Imidazopyrimidines and Imidazopyrazines: The Role of Nitrogen Position in Inotropic Activity
Spitzer, Wayne A.,Victor, Frantz,Pollock, G. Don,Hayes, J. Scott
, p. 1590 - 1595 (2007/10/02)
Congestive heart failure is a major medical problem for which existing medicaments have provided limited benefit.Recent new experimental drugs, including imidazo- and imidazopyridines, have both inotropic and vasodilatory properties.Subtle c
