114560-48-4 Usage
Uses
Used in Pharmaceutical Industry:
APAZIQUONE,1H-INDOLE-4,7-DIONE, 5-(1-AZIRIDINYL)-3-(HYDROXYMETHYL)-2-(3-HYDROXY-1-PROPENYL)-1-METHYL-, (E)is used as a therapeutic agent for the treatment of non-muscle invasive bladder cancer. It works by taking advantage of the hypoxic environment within the tumor, where it is activated and exerts its cytotoxic effects, leading to the destruction of cancer cells and inhibition of tumor growth.
Additionally, due to its bioreductive nature, APAZIQUONE has the potential to be used in combination with other chemotherapeutic agents to enhance their efficacy and overcome drug resistance in various types of cancer. This targeted approach may also reduce the risk of side effects and improve the overall quality of life for patients undergoing cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 114560-48-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,5,6 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 114560-48:
(8*1)+(7*1)+(6*4)+(5*5)+(4*6)+(3*0)+(2*4)+(1*8)=104
104 % 10 = 4
So 114560-48-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H16N2O4/c1-16-10(3-2-6-18)9(8-19)13-14(16)12(20)7-11(15(13)21)17-4-5-17/h2-3,7,18-19H,4-6,8H2,1H3/b3-2+
114560-48-4Relevant academic research and scientific papers
Kinugawa,Masuda,Arai,Nishikawa,Ogasa,Tomioka,Kasai
, p. 633 - 636 (1996)
A convenient large scale preparation of the indoloquinone antitumor agent EO 9 (1) has been developed. The hazardous reagent, Fremy's salt, was replaced by a safer one, [bis(trifluoroacetoxy)iodo]benzene, for oxidation of the 4-aminoindole 3 to the corresponding indoloquinone 4, and high quality 1 was easily obtained by choosing acetonitrile as the reaction solvent for substitution of the methoxy group with ethylenimine to introduce the aziridinyl group into EO 7 (6).
