114564-75-9Relevant academic research and scientific papers
5-Oxazolones, IV Reactions of 5(4H)-Oxazolones with Triphenylphosphonium Methylides
Erba, Emanuela,Gelmi, Maria Luisa,Pocar, Donato
, p. 1519 - 1524 (2007/10/02)
The Wittig reaction of ethyl (triphenylphosphoranylidene)acetate (2a) with the carbonyl group of trisubstituted 5(4H)-oxazolones 1a-c afforded ethyl 5(4H)-oxazolylideneacetates 3a-c and triphenylphosphane oxide.Starting from oxazolones 1d-i and ylide 2a, methyleneoxazoles 3d, e and ethyl 5-oxazoleacetates 4a-f were obtained besides ylides 5a-e deriving from the nucleophilic attack of the ylide at 1 and subsequent opening of the oxazole ring.Oxazolones 1a-c reacted also with triphenylphosphonium phenylmethylide (2b) to yield methyleneoxazoles 3f,g and ylides 5f-h.By treating triphenylphosphonium methylide (2c) and -methoxymethylide (2d) with 1a-c only open-chain compounds 5i-k and 5l-n, respectively, were obtained.
