1145667-70-4Relevant academic research and scientific papers
1,4-Diazepanes derived from (S)-serine - Homopiperazines with improved σ1 (sigma) receptor affinity and selectivity
Beduerftig, Stephan,Wuensch, Bernhard
, p. 519 - 525 (2009)
Starting from the proteinogenic amino acid (S)-serine chiral non-racemic 1,4-diazepanes 4 with a hydroxymethyl residue in position 2 are synthesized and pharmacologically evaluated. The key step in the synthesis is the formation of the bicyclic system 8 b
