1145667-93-1Relevant articles and documents
The identification of orally bioavailable thrombopoietin agonists
Munchhof, Michael J.,Antipas, Amy S.,Blumberg, Laura C.,Brissette, William H.,Brown, Matthew F.,Casavant, Jeffrey M.,Doty, Jonathan L.,Driscoll, James,Harris, Thomas M.,Wolf-Gouveia, Lilli A.,Jones, Christopher S.,Li, Qifang,Linde, Robert G.,Lira, Paul D.,Marfat, Anthony,McElroy, Eric,Mitton-Fry, Mark,McCurdy, Sandra P.,Reiter, Lawrence A.,Ripp, Sharon L.,Shavnya, Andrei,Thomasco, Lisa M.,Trevena, Kristen A.
body text, p. 1428 - 1430 (2009/10/15)
Recently, we disclosed a series of potent pyrimidine benzamide-based thrombopoietin receptor agonists. Unfortunately, the structural features required for the desired activity conferred physicochemical properties that were not favorable for the developmen
