1145668-33-2

Upstream product

• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 542-69-8 1-iodo-butane 
• 1015792-22-9 1-(3,4,5-trimethoxyphenyl)-β-carboline-3-carboxylic acid ethyl ester 
• 73-22-3 L-Tryptophan 
• 1160060-51-4 ethyl 1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylate 
• 342013-69-8 1-(3,4,5-trimethoxy)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid 

Downstream Products

• 1145668-35-4 ethyl 1-(3,4,5-trimethoxy)phenyl-9-n-butyl-β-carboline-3-carboxylic acid 
• 1145668-39-8 1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-n-butyl-β-carboline 
• 1145668-37-6 N-(2-hydroxyethyl)-1-(3,4,5-trimethoxy)phenyl-9-n-butyl-β-carboline-3-formamide 
• 1145668-42-3 1-(3,4,5-trimethoxy)phenyl-9-n-butyl-β-carboline-3-carboxaldehyde 

Relevant academic research and scientific papers

Synthesis and biological evaluation of piperazine group-linked bivalent β-carbolines as potential antitumor agents

A series of novel bivalent β-carbolines with a piperazine group spacer between 3-methylene units were synthesized and evaluated as antitumor agents. The results demonstrated that compounds 7e and 7g exhibited the most potent cytotoxic activities against ten tumor cell lines. Structure-activity relationships analysis indicated that (1) the substituents in positions 1 and 9 of the β-carboline ring played a significant role in modulating the antitumor activity; (2) the introduction of alkyl groups into position-9 of the β-carboline nucleus enhanced their cytotoxic potencies and the butyl substituent was the optimal group. Investigation of the preliminary mechanism of action demonstrated that compound 7g showed obvious anti-angiogenic activity in the in vivo CAM assay, and the potency was similar to that of CA4P (200 μM).