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(R)-8-(trifluoromethyl)chroman-4-amine, commonly known as Tofacitinib, is a pharmaceutical compound that functions as a Janus kinase (JAK) inhibitor. It is characterized by its ability to target and inhibit specific enzymes involved in inflammatory processes, thereby reducing inflammation and associated pain. Tofacitinib is available in tablet form for oral administration and has been approved for medical use in several countries to treat conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

1145685-65-9

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1145685-65-9 Usage

Uses

Used in Pharmaceutical Industry:
Tofacitinib is used as an anti-inflammatory medication for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It operates by inhibiting the activity of Janus kinase enzymes, which play a crucial role in the inflammatory response. This inhibition helps to alleviate the symptoms of these conditions, including pain and inflammation.
Used in Clinical Trials:
Tofacitinib has been utilized in clinical trials to evaluate its efficacy and safety in treating various inflammatory and autoimmune diseases. The results from these trials have demonstrated its potential as a therapeutic agent, leading to its approval for medical use in several countries.
Used in Medication Formulation:
As a tablet form for oral administration, Tofacitinib is used in the formulation of medications designed to manage and reduce the severity of inflammatory conditions. Its formulation allows for convenient and effective dosing under the guidance of healthcare professionals.

Check Digit Verification of cas no

The CAS Registry Mumber 1145685-65-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,5,6,8 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1145685-65:
(9*1)+(8*1)+(7*4)+(6*5)+(5*6)+(4*8)+(3*5)+(2*6)+(1*5)=169
169 % 10 = 9
So 1145685-65-9 is a valid CAS Registry Number.

1145685-65-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (4R)-8-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-amine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1145685-65-9 SDS

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