114591-12-7

Upstream product

• 114591-07-0 (R)-2-[3-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-1H-indol-4-ylamino]-3-phenyl-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 114591-07-0 (R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-1H-indol-4-ylamino]-3-phenyl-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 114591-00-3 (S)-2-[3-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-1H-indol-4-ylamino]-3-phenyl-propionic acid ethyl ester 
• 114591-06-9 (S)-2-[3-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-1H-indol-4-ylamino]-3-phenyl-propionic acid 
• 84590-34-1 (+/-)-N-Boc-4-aminotryptophanol 
• 101308-40-1 ethyl 2-bromo-3-phenylpropionate 
• 114591-00-3 (S)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-1H-indol-4-ylamino]-3-phenyl-propionic acid ethyl ester 
• 114591-06-9 (R)-2-[3-((R)-2-tert-Butoxycarbonylamino-3-hydroxy-propyl)-1H-indol-4-ylamino]-3-phenyl-propionic acid 

Downstream Products

• 110073-29-5 epi-indolactam-F 
• 110073-29-5 indolactam-F 

Relevant academic research and scientific papers

Synthesis and Stereochemistry of Indolactam Congeners. Conformational Behavior of the Nine-membered Lactams.

The potent tumor promoters teleocidins and (-)-indolactam-V, which is a biologically active partial structure, exist in two conformational states (SOFA and TWIST forms) in solution.In order to examine the effect of the C-12 isopropyl group, a series of indolactams having a methyl, benzyl, isobutyl or tert-butyl group at the C-12 position instead of the isopropyl group have been synthesized. 1H-NMR measurements have shown that incresing bulkiness of the substituent on C-12 tends to increase the relative population of the SOFA conformer.