114604-72-7Relevant academic research and scientific papers
Novel human histamine H(3) receptor antagonists.
Shah, Chandra,McAtee, Laura,Breitenbucher, J Guy,Rudolph, Dale,Li, Xiaobing,Lovenberg, Timothy W,Mazur, Curt,Wilson, Sandy J,Carruthers, Nicholas I
, p. 3309 - 3312 (2007/10/03)
High throughput screening, using the recombinant human H(3) receptor, was used to identify novel histamine H(3) receptor antagonists. Evaluation of the lead compounds ultimately afforded potent, selective, orally bioavailable compounds (e.g., 38) with fav
Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity
Sanfilippo,Urbanski,Press,Dubinsky,Moore Jr.
, p. 2221 - 2227 (2007/10/02)
A series of imidazo-fused heterocycles substituted with an (aryloxy)alkylamine side chain were prepared as modifications to butoprozine (I) and found to possess calcium channel blocking activity similar in potency to that of bepridil in trachea smooth mus
