1146066-75-2

Upstream product

• 1146066-58-1 C₃₉H₃₆N₂O₁₂ 
• 122-00-9 para-methylacetophenone 
• 1146066-41-2 C₂₅H₁₈N₂O₃ 
• 42059-55-2 7-hydroxy-3-formylchromone 
• 1146066-31-0 C₁₉H₁₄O₄ 

Relevant academic research and scientific papers

Computational evaluation and experimental verification of antibacterial and antioxidant activity of 7-hydroxy-3-pyrazolyl-4H-chromen-4-ones and their o-glucosides: Identification of pharmacophore sites

This paper reports the computational evaluation and experimental verification of 7-hydroxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl)-4H-chromen-4-ones 3 and their o-β-d-glucopyranosides 5 for their antimicrobial and antioxidant activity. The prepared compounds

Synthesis and biological activities of new hydroxy-3-pyrazolyl-4H-chromen- 4-ones and their O-glucosides

The synthesis of a number of 7-hydroxy-3-pyrazolyl-chromen-4H-ones and their o-glucosides has been described. 7-Hydoxy-3-formyl chromen-4H-one 1 on condensation with substituted acetophenones in the presence of piperidine in dry alcohol affords 7-hydroxy-3-(3-oxo-3-arylprop-1-enyl)-4H-chromen-4-ones 2 which on cyclization with phenyl hydrazine hydrochloride leads to the formation of 7-hydroxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl)-4H-chromen-4-ones 3. 7-o-β-D-Glucopyranosyloxy-3-(1-phenyl-3-aryl-1H-pyrazol-5-yl) -4H-chromen-4-ones 5 have been synthesized by the reaction of 2, 3, 4, 6-tetra-o-acetyl-α-D-glucopyranosyl bromide with potassium salt of 3 followed by deacetylation with Zn(CH3COO)2 in absolute methanol. Some of the newly synthesized compounds have been screened for their antimicrobial and antioxidant activity.