1146096-85-6Relevant articles and documents
Potent oligomerization and macrocyclization activity of the thioesterase domain of vicenistatin polyketide synthase
Kudo, Fumitaka,Asou, Yusaku,Watanabe, Moe,Kitayama, Takashi,Eguchi, Tadashi
, p. 1843 - 1846 (2012)
The thioesterase domain of the polyketide synthase involved in the biosynthesis of the 20-membered macrolactam antibiotic vicenistatin (VinTE) was found to catalyze oligomerization and macrocyclization of ω-hydroxy fatty acid ethyl esters to afford 17-28-membered macrocyclic lactones. The ring sizes of the macrocycles appear to be limited to the more moderate sizes because of the space limitation of the active site of VinTE. It was also verified that the initially formed linear dimer is first released from the active site of VinTE and then is recognized again by VinTE prior to its transformation to the cyclic dimer.
Mild method for the selective esterification of carboxylic acids based on the Garegg-samuelsson reaction
Morcillo, Sara P.,Alvarez De Cienfuegos, Luis,Mota, Antonio J.,Justicia, Jose,Robles, Rafael
supporting information; experimental part, p. 2277 - 2281 (2011/05/19)
A mild method for the selective esterification of primary alcohols is described. The use of different phosphines, I2, and imidazole allows the selective esterification of a wide variety of acids with excellent results. The generation of a bulky phosphonium-carboxylate salt as intermediate could justify the selectivity observed in this process. Additionally, amides also can be synthesized with use of this method.
