1146137-53-2Relevant academic research and scientific papers
Transition-metal-free α-arylation of oxindoles: Vi a visible-light-promoted electron transfer
Liang, Kangjiang,Li, Na,Zhang, Yang,Li, Tao,Xia, Chengfeng
, p. 3049 - 3053 (2019/03/13)
An operationally simple photochemical strategy for the direct arylation of oxindoles with (hetero)aryl halides in the absence of both transition metals and photoredox catalysts has been developed. The reaction provides an efficient way to construct various 3-aryloxindole building blocks of pharmaceutical interest at ambient temperature by using household compact fluorescent light (CFL) bulbs as the light source. Preliminarily, mechanistic studies revealed that the intermolecular electron transfer relied on the formation of photon-absorbing electron-donor-acceptor (EDA) complexes between electron-rich oxindole enolates and electron-deficient (hetero)aryl halides, and a radical chain mechanism was operative.
Oxindole synthesis by direct coupling of Csp2-H and C sp3-H centers
Jia, Yi-Xia,Kuendig, E. Peter
supporting information; experimental part, p. 1636 - 1639 (2009/06/30)
(Chemical Equation Presented) An sp2/sp3 get-together: A novel and efficient method can be used to synthesize 3,3-disubstitued oxindoles by the direct intramolecular oxidative coupling of an aryl Csp2-H and a Csp3-H center (see scheme; DMF = N,N-dimethylformamide).
