1146213-82-2Relevant academic research and scientific papers
Investigations of SCIO-469-like compounds for the inhibition of p38 MAP kinase
Laufer, Stefan,Lehmann, Frank
supporting information; experimental part, p. 1461 - 1464 (2009/11/30)
The p38 MAP kinase is implicated in the release of the pro-inflammatory cytokines TNFα and IL-1b. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A new lead structure for p38 MAP kinase inhibition was identified. Herein, we report the SAR of this new class of p38 inhibitors.
