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1146214-95-0

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1146214-95-0 Usage

General Description

2-Chloro-5-(trifluoromethyl)phenylboronic acid pinacol ester is a boronic acid derivative commonly used in organic synthesis. It is a versatile reagent for the construction of carbon-carbon bonds and is often employed in cross-coupling reactions to form new carbon-carbon bonds. 2-Chloro-5-(trifluoromethyl)phenylboronic acid pinacol ester is valuable for the preparation of various pharmaceuticals, agrochemicals, and materials. Its unique structure and functional groups make it a valuable tool for the synthesis of complex organic molecules. Additionally, its pinacol ester moiety provides stability and can be easily removed under mild conditions in the final steps of the synthesis, making it a useful building block in organic chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 1146214-95-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,6,2,1 and 4 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1146214-95:
(9*1)+(8*1)+(7*4)+(6*6)+(5*2)+(4*1)+(3*4)+(2*9)+(1*5)=130
130 % 10 = 0
So 1146214-95-0 is a valid CAS Registry Number.

1146214-95-0Downstream Products

1146214-95-0Relevant articles and documents

Investigation of a lithium-halogen exchange flow process for the preparation of boronates by using a cryo-flow reactor

Newby, James A.,Huck, Lena,Blaylock, D. Wayne,Witt, Paul M.,Ley, Steven V.,Browne, Duncan L.

, p. 263 - 271 (2014/01/17)

Conducting low-temperature organometallic reactions under continuous flow conditions offers the potential to more accurately control exotherms and thus provide more reproducible and scalable processes. Herein, progress towards this goal with regards to the lithium-halogen exchange/borylation reaction is reported. In addition to improving the scope of substrates available on a research scale, methods to improve reaction profiles and expedite purification of the products are also described. On moving to a continuous system, thermocouple measurements have been used to track exotherms and provide a level of safety for continuous processing of organometallic reagents. The use of an in-line continuous liquid-liquid separation device to circumvent labour intensive downstream off-line processing is also reported. A cool setup: A small footprint, modular setup based around a cryo-flow reactor is reported for the preparation of gram quantities of boronic esters. With minimum alteration, including the addition of a data logger with thermocouples and a liquid-liquid separator, the same equipment can be used to scale the process, inclusive of an in-line extraction. Copyright

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