114622-04-7

Basic information

• Product Name: 9H-quino[4,3,2-de][1,10]phenanthrolin-9-one
• Synonyms: Ascididemine
• CAS NO: 114622-04-7
• Molecular Formula: C₁₈H₉N₃O
• Molecular Weight: 283.2836
• Mol File: 114622-04-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 600.1°C at 760 mmHg
• Flash Point: 303.4°C
• Density: 1.469g/cm³
• Vapor Pressure: 2.32E-14mmHg at 25°C
• Refractive Index: 1.819
• CAS DataBase Reference: 9H-quino[4,3,2-de][1,10]phenanthrolin-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-quino[4,3,2-de][1,10]phenanthrolin-9-one(114622-04-7)
• EPA Substance Registry System: 9H-quino[4,3,2-de][1,10]phenanthrolin-9-one(114622-04-7)

Safety Data

• Hazardous Substances Data: 114622-04-7(Hazardous Substances Data)

Upstream product

• 25368-52-9 1-dimethylamino-1-azabuta-1,3-diene 
• 264870-27-1 4-bromo-6H-pyrido[2,3,4-kl]acridin-6-one 
• 4008-48-4 nitroxoline 
• 13207-66-4 5-amino-8-hydroxyquinoline 
• 227288-15-5 tert-butyl [3-(2-aminophenyl)prop-2-yn-1-yl]carbamate 
• 1394900-53-8 4-(2-fluorophenyl)-3’-methyl-2,2’-bipyridine-3-carbonitrile 
• 65115-91-5 5,6-epoxy-5,6-dihydro-[1,10]phenanthroline 
• 142009-79-8 trans-5-anilino-6-hydroxy-5,6-dihydro-1,10-phenanthroline 
• 142009-78-7 N-phenyl-1,10-phenanthroline-5,6-quinone monoimine 
• 132114-06-8 trans-5-(2-iodoanilino)-6-hydroxy-5,6-dihydro-1,10-phenanthroline 
• 142009-77-6 diethyl N-(2-iodophenyl)-phosphoramidate 
• 5144-89-8 1,10-phenanthroline hydrate 
• 615-43-0 2-iodophenylamine 
• 27318-90-7 1,10-phenanthroline-5,6-dione 

Relevant articles and documents

Chemistry of 2-bromoleptoclinidinone, structure revision

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Structural studies of cytotoxic marine alkaloids: Synthesis of novel ring-E analogues of ascididemin and their in vitro and in vivo biological evaluation

The cytotoxic marine alkaloid ascididemin and various pyridine ring-E analogues have been synthesised in an attempt to determine the pharmaceutical utility and structure-activity requirements for the parent alkaloid. All compounds synthesised were evaluated in a wide range of biological screens for selective cytotoxicity, antiviral, antifungal and antimicrobial properties. Many analogues exhibited selective cytotoxicity to human solid tumour cell-lines in vitro, with one also exhibiting moderate antitumour activity in in vivo xenograft assays. (C) 2000 Elsevier Science Ltd.

Total synthesis of ascididemin-type alkaloids using alkyne building blocks

A common approach to ascididemin-type alkaloids, including ascididemin, bromoleptoclinidinone, neocalliactine acetate, and 11-hydroxyascididemin, based on a Bronsted acid-promoted tandem annulation has been developed. Alkyne building blocks were first des

Intramolecular Michael-type addition of azadienes to 1,4-naphthoquinones instead of Aza-Diels-Alder cycloaddition: A synthesis of ascididemin

α,β-Unsaturated hydrazones tethered by an amino group to 1,4-naphthoquinone or quinoline-5,8-dione do not react by intramolecular aza-Diels-Alder cycloaddition. Instead, these substrates cyclize to form benzo[b]acridine-6,11-dione or pyrido[2,3-b]acridine-5,12-dione derivatives, respectively. This route leads to a highly concise synthesis of the pyridoacridine alkaloid ascididemin.