114628-12-5

Basic information

• Product Name: trans-N-benzyl-4-hydroxy-5-(iodomethyl)pyrrolidin-2-one
• CAS NO: 114628-12-5
• Molecular Weight: 331.153
• Mol File: 114628-12-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-N-benzyl-4-hydroxy-5-(iodomethyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: trans-N-benzyl-4-hydroxy-5-(iodomethyl)pyrrolidin-2-one(114628-12-5)
• EPA Substance Registry System: trans-N-benzyl-4-hydroxy-5-(iodomethyl)pyrrolidin-2-one(114628-12-5)

Safety Data

• Hazardous Substances Data: 114628-12-5(Hazardous Substances Data)

Upstream product

• 123076-22-2 N-benzyl-3-hydroxypent-4-enethioamide 
• 114628-09-0 N-Benzyl-3-hydroxy-pent-4-enimidothioic acid methyl ester 

Downstream Products

• 123076-45-9 trans-N-benzyl-3-hydroxy-2-<(triphenylmethoxy)methyl>pyrrolidine 
• 123076-45-9 cis-N-benzyl-3-hydroxy-2-<(triphenylmethoxy)methyl>-pyrrolidine 
• 121686-87-1 cis-N-benzyl-2-(hydroxymethyl)-3-hydroxypyrrolidin-2-one 
• 105017-31-0 (2S,3S)-2-Hydroxymethyl-pyrrolidin-3-ol 
• 105017-31-0 (+/-)-(2R*,3R*)-2-hydroxymethylpyrrolidin-3-ol 
• 123076-46-0 trans-N-benzyl-3-(benzoyloxy)-2-<(triphenylmethoxy)methyl>pyrrolidine 
• 123098-76-0 cis-N-benzyl-4-<(tert-butyldimethylsilyl)oxy>-5-<<(tert-butyldimethylsilyl)oxy>methyl>pyrrolidin-2-one 
• 123076-53-9 cis-N-benzyl-4-<(tert-butyldimethylsilyl)oxy>-5-(3-carbethoxypropyl)pyrrolidine-2-thione 
• 123076-52-8 4-[(2R,3R)-1-Benzyl-3-(tert-butyl-dimethyl-silanyloxy)-5-oxo-pyrrolidin-2-yl]-butyric acid ethyl ester 
• 123076-54-0 cis-N-benzyl-3-<(tert-butyldimethylsilyl)oxy>-2-(3-carbethoxypropyl)pyrrolidine 
• 121686-86-0 cis-N-benzyl-4-hydroxy-5-(hydroxymethyl)pyrrolidin-2-one 
• 123076-51-7 cis-N-benzyl-4-hydroxy-5-(3-carbethoxypropyl)pyrrolidin-2-one 
• 123076-40-4 cis-N-benzyl-5-(acetoxymethyl)-4-hydroxypyrrolidin-2-one 

Relevant articles and documents

Electrophilic Olefin Heterocyclization in Organic Synthesis. Stereoselective Synthesis of 4,5-Disubstituted γ-Lactams by Iodine-Induced Lactam Formation of γ,δ-Unsaturated Thioimidates

Iodine-induced lactamization of γ,δ-unsaturated thioimidates proceeds regioselectively to provide γ-lactams.The iodolactamization with allylic substituents brings about 1,2-asymmetric induction, which depends on the allyl groups.Transformation of the cis-4-hydroxy-5-(iodomethyl)pyrrolidin-2-one (24a) among these highly functionalized γ-lactams into several biologically active compounds is described.In addition, the conversion of an optically active form of 24a is discussed.