114628-32-9Relevant articles and documents
Bioinspired Diastereoconvergent Synthesis of the Tricyclic Core of Palodesangrens via Diels-Alder Reaction, LiAlH4-Mediated Isomerization, and Acid-Mediated Cyclization
Songthammawat, Poramate,Wangngae, Sirilak,Matsumoto, Koki,Duangkamol, Chuthamat,Ruchirawat, Somsak,Ploypradith, Poonsakdi
, p. 5225 - 5241 (2018/05/07)
The cyclohexene moiety of the tricyclic 6,7-diaryl-tetrahydro-6H-benzo[c]chromene core of palodesangrens could be assembled in a biomimetic and step-economical fashion by the Diels-Alder reaction between the electron-rich (E)-1,3-butadienylarenes as the diene and the electron-deficient chalcones as the dienophile. During the reduction of ketone to the corresponding alcohol by LiAlH4, the mixture of endo and exo isomers underwent a novel diastereoconvergent LiAlH4-mediated isomerization to install the desired stereochemistry at C10a. Subsequent pyran ring closure under acidic conditions installed the stereochemistry at the remaining C6. Overall, the tricyclic core of palodesangrens could be prepared in three steps and up to 38% yield.
Compound having acyl coa:cholesterol acyltransferase inhibitory and composition for prevention or treatment of cardiovascular disease comprising thereof
-
Paragraph 0068-0069, (2017/08/08)
The present invention relates to: a compound denoted by chemical formula 1 or pharmaceutically acceptable salt thereof; and a composition for preventing or treating cardiovascular diseases containing the same as an effective component. The compound or the
Facile synthesis of diarylmethanes via quinone methides
Tangdenpaisal, Kassrin,Phakhodee, Wong,Ruchirawat, Somsak,Ploypradith, Poonsakdi
, p. 933 - 941 (2013/07/25)
A novel acid-mediated generation of quinone methides followed by nucleophilic addition of electronrich aromatic compounds to furnish diarylmethanes has been developed. A wide range of electronrich aromatic compounds including some heterocycles can be employed for this reaction to provide the corresponding diarylmethanes in good yields and regioselectivities.