1146352-89-7

Upstream product

• 65253-04-5 (-)-8-phenylmenthol 
• 75-52-5 nitromethane 
• 1146352-87-5 [(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 7-oxocyclohept-1-enecarboxylate 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 1146352-83-1 [(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl] 2-oxocycloheptanecarboxylate 
• 502-42-1 cycloheptanone 

Relevant academic research and scientific papers

Stereocontrolled Construction of ABCD Tetracyclic Ring System with Vicinal All-Carbon Quaternary Stereogenic Centers of Calyciphylline A Type Alkaloids

A unique approach to the synthesis of an ABCD tetracyclic core bearing the vicinal all-carbon quaternary stereogenic centers of the calyciphylline A type alkaloids is reported. The synthesis features two C-C bond formations at a sterically congested position: one is an intramolecular pinacol coupling to construct the central A ring; the other is a semipinacol rearrangement to construct a quaternary stereogenic center adjacent to another quaternary center.

Synthetic studies on daphnicyclidin A: enantiocontrolled construction of the BCD ring system

An enantiocontrolled entry to the tricyclic core of daphnicyclidin A with five chlral centers Including an all-carbon quaternary center Is reported. The synthesis features a highly dlastereoselectlve conjugate addition of nltromethane, an Ireland- Clalsen rearrangement, and a tandem acyliminium/ Mannich- type reaction.