1146403-59-9Relevant academic research and scientific papers
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors
Zhao, Zhijian,Leister, William H.,O'Brien, Julie A.,Lemaire, Wei,Williams Jr., David L.,Jacobson, Marlene A.,Sur, Cyrille,Kinney, Gene G.,Pettibone, Doug J.,Tiller, Philip R.,Smith, Sheri,Hartman, George D.,Lindsley, Craig W.,Wolkenberg, Scott E.
, p. 1488 - 1491 (2009)
Employing an iterative analogue library approach, novel potent and selective glycine transporter 1 (GlyT1) inhibitors containing a 4-pyridin-2-ylpiperidine sulfonamide have been discovered. These inhibitors are devoid of time-dependent CYP inhibition activity and exhibit improved aqueous solubility versus the corresponding 4-phenylpiperidine analogues.
