114650-47-4

Upstream product

• 100-17-4 para-methoxynitrobenzene 
• 13170-43-9 (trimethylsilyl)methylmagnesium chloride 

Downstream Products

• 117616-03-2 (E)-N-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-3-phenyl-acrylamide 
• 117616-04-3 4-methoxy-2-trimethylsilylmethylbenzanilide 
• 117615-96-0 (E)-N-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-N-methyl-3-phenyl-acrylamide 
• 117615-97-1 N-(4-Methoxy-2-trimethylsilanylmethyl-phenyl)-N-methyl-benzamide 
• 117615-99-3 (4-Methoxy-2-trimethylsilanylmethyl-phenyl)-methyl-carbamic acid methyl ester 
• 117616-08-7 5-Methoxy-1-methyl-2-((E)-styryl)-1H-indole 
• 117616-09-8 5-methoxy-1-methyl-2-phenyl-1H-indole 
• 117616-06-5 (4-Methoxy-2-trimethylsilanylmethyl-phenyl)-carbamic acid methyl ester 

Relevant academic research and scientific papers

Intramolecular Peterson Olefination of ortho-Trimethylsilylmethyl Anilides: a New Synthesis of N-Methylindoles

A modified Madelung synthesis of indoles by cyclisation of ortho-trimethylsilylmethyl anilides under mild conditions is reported.

ONE-POT CHEMOSELECTIVE REDUCTIVE ALKYLATION OF NITROARENES: A NEW GENERAL METHOD OF SYNTHESIS OF ALKYLANILINES.

A New facile and general synthesis of alkylanilines by one-pot reductive alkylation of nitroarenes is reported.This method is based on the "in situ" reduction by hydrides (LiAlH4 or NaBH4) in the presence of catalytic amounts of Pd/C, of nitronate adducts arising from the conjugate addition of Grignard reagents to mononitroarenes.LiAlH4 showed to be a more efficient but less selective reducing agent than NaBH4.The reaction can be successfully applied to mono, homo and hetero bicyclic systems and allows to introduce a large variety of alkyl chains without isomerisation phenomena.