114661-01-7 Usage
Uses
Used in Cancer Immunotherapy:
3-O-(2-acetamido-6-O-(N-acetylneuraminyl)-2-deoxygalactosyl)serine is used as a cancer-specific target for immunotherapy. The Sialosyl-Tn epitope serves as a marker for various types of cancer, making it a promising candidate for the development of targeted therapies. By leveraging the immune system to recognize and attack cancer cells displaying this antigen, immunotherapy can potentially improve patient outcomes and reduce the side effects associated with traditional cancer treatments.
Used in Diagnostic Monoclonal Antibodies:
3-O-(2-acetamido-6-O-(N-acetylneuraminyl)-2-deoxygalactosyl)serine is also used in the development of diagnostic monoclonal antibodies. The Sialosyl-Tn epitope's presence in cancer cells allows for the creation of antibodies that can specifically bind to and detect these cells. This targeted approach can lead to more accurate and sensitive diagnostic tests, helping to identify cancer at earlier stages and guide more effective treatment strategies.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-O-(2-acetamido-6-O-(N-acetylneuraminyl)-2-deoxygalactosyl)serine is used as a key component in the development of novel drug delivery systems. Its unique chemical properties and cancer-specific targeting capabilities make it an attractive candidate for the design of targeted drug carriers, which can improve the bioavailability and therapeutic outcomes of various cancer treatments.
Used in Research and Development:
3-O-(2-acetamido-6-O-(N-acetylneuraminyl)-2-deoxygalactosyl)serine is also utilized in research and development for its potential applications in cancer biology, immunology, and drug discovery. Its role as a cancer-associated antigen and its chemical properties make it a valuable tool for studying the underlying mechanisms of cancer progression and for identifying new therapeutic targets.
Check Digit Verification of cas no
The CAS Registry Mumber 114661-01-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,6,6 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 114661-01:
(8*1)+(7*1)+(6*4)+(5*6)+(4*6)+(3*1)+(2*0)+(1*1)=97
97 % 10 = 7
So 114661-01-7 is a valid CAS Registry Number.
InChI:InChI=1/C22H37N3O16/c1-7(27)24-13-10(29)3-22(21(36)37,41-18(13)15(31)11(30)4-26)39-6-12-16(32)17(33)14(25-8(2)28)20(40-12)38-5-9(23)19(34)35/h9-18,20,26,29-33H,3-6,23H2,1-2H3,(H,24,27)(H,25,28)(H,34,35)(H,36,37)/t9-,10-,11+,12+,13+,14+,15+,16-,17+,18+,20-,22+/m0/s1
114661-01-7Relevant academic research and scientific papers
TOTAL SYNTHESIS OF 3-O--L-SERINE AND A STEREOISOMER
Iijima, Hiroyuki,Ogawa, Tomoya
, p. 183 - 194 (2007/10/02)
O-(5-Acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-O-(2-acetamido-2-deoxy-α-D-galactopyranosyl)-(1->3)-L-serine, a structural unit occuring in various submaxillary mucins, was sythesized for the first time by using O--(2->6)-3,4-di-O-acetyl-2-azido-2-deoxy-D-galactopyranosyl trichloroacetimidate (13) and N-(benzyloxycarbonyl)-L-serine benzyl ester as the key intermediates.The trichloroacetimidate 13 was prepared by starting from two monosaccharide synthons, namely, allyl 2-azido-2-deoxy-β-D-galactopyranoside and methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-β-D-galacto-2-nonulopyranosyl chloride)onate, which were coupled in the presence of silver triflate in tetrahydrofuran to give the desired α-(2->6)-linked disaccharide in moderate selectivity.
