1146629-74-4 Usage
Uses
Used in Pharmaceutical Industry:
(R)-2-(bis(3,5-bis(trifluoromethyl)phenyl)(tert-butyldimethylsilyloxy)methyl)pyrrolidine is used as a pharmaceutical intermediate for the synthesis of various drug candidates due to its unique structure and functional groups, which can be further modified to target specific biological pathways or receptors.
Used in Materials Science:
In the materials science field, (R)-2-(bis(3,5-bis(trifluoromethyl)phenyl)(tert-butyldimethylsilyloxy)methyl)pyrrolidine is used as a building block for the development of novel materials with specific properties, such as high thermal stability, chemical resistance, or unique electronic characteristics, owing to the presence of trifluoromethyl and tert-butyldimethylsilyloxy groups.
Used in Chemical Research:
(R)-2-(bis(3,5-bis(trifluoromethyl)phenyl)(tert-butyldimethylsilyloxy)methyl)pyrrolidine serves as a valuable research tool in chemical synthesis, allowing chemists to explore new reaction pathways, develop innovative synthetic methods, and investigate the properties of this complex molecule, ultimately contributing to the advancement of chemical science.
Check Digit Verification of cas no
The CAS Registry Mumber 1146629-74-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,6,6,2 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1146629-74:
(9*1)+(8*1)+(7*4)+(6*6)+(5*6)+(4*2)+(3*9)+(2*7)+(1*4)=164
164 % 10 = 4
So 1146629-74-4 is a valid CAS Registry Number.
1146629-74-4Relevant academic research and scientific papers
PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS
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Page/Page column 67-68, (2010/08/07)
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
Enantioselective synthesis of janus kinase inhibitor INCB018424 via an organocatalytic aza-michael reaction
Lin, Qiyan,Meloni, David,Pan, Yongchun,Xia, Michael,Rodgers, James,Shepard, Stacey,Li, Mei,Galya, Laurine,Metcalf, Brian,Yue, Tai-N,Liu, Pingli,Zhou, Jiacheng
supporting information; experimental part, p. 1999 - 2002 (2009/09/06)
An enantioselective synthesis of INCB018424 via organocatalytic asymmetric aza-Michael addition of pyrazoles (16 or 20) to (E)-3- cyclopentylacrylaldehyde (23) using diarylprolinol silyl ether as the catalyst was developed. Michael adducts (R)-24 and (R)-27 were isolated in good yield and high ee and were readily converted to INCB018424.
