ARRY-543 is a selective and potent inhibitor of ErbB1 and ErbB2 receptors, with an IC50 of 7 nM and 2 nM, respectively. It is a small molecule compound designed to target and inhibit the activity of these receptors, which are often overexpressed in various types of cancer cells.
1146629-86-8
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Basic information
- Product Name: ARRY-543
- Synonyms: N4-[3-Chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-quinazolinediamine 4-methylbenzenesulfonate;Varlitinib tosylate;ARRY-543 TOSYLATE;N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-Quinazolinediaminebis(4-methylbenzenesulfonate)
- CAS NO:1146629-86-8
- Molecular Formula: C29H27ClN6O5S2
- Molecular Weight: 639.14488
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1146629-86-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: ARRY-543(CAS DataBase Reference)
- NIST Chemistry Reference: ARRY-543(1146629-86-8)
- EPA Substance Registry System: ARRY-543(1146629-86-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1146629-86-8(Hazardous Substances Data)
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1146629-86-8 Usage
Uses
Used in Pharmaceutical Industry:ARRY-543 is used as an anticancer agent for its ability to selectively and potently inhibit the ErbB1 and ErbB2 receptors. This inhibition can help in the treatment of various types of cancer, particularly those with overexpression of these receptors, by preventing the activation of oncogenic signaling pathways and subsequent tumor growth and progression.
Used in Drug Development:
ARRY-543 is used as a research tool in the development of new cancer therapies. Its selective and potent inhibition of ErbB1 and ErbB2 receptors makes it a valuable compound for studying the role of these receptors in cancer and for identifying potential synergistic effects when combined with other targeted therapies or conventional chemotherapeutic drugs.
Used in Preclinical Research:
ARRY-543 is used as a preclinical model to evaluate the efficacy and safety of ErbB1 and ErbB2 inhibition in various cancer types. This helps researchers understand the potential benefits and risks associated with targeting these receptors and informs the design of future clinical trials and therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 1146629-86-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,6,6,2 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.Calculate Digit Verification of CAS Registry Number 1146629-86:
(9*1)+(8*1)+(7*4)+(6*6)+(5*6)+(4*2)+(3*9)+(2*8)+(1*6)=168
168 % 10 = 8
So 1146629-86-8 is a valid CAS Registry Number.
1146629-86-8Upstream product
1146629-86-8Downstream Products
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ARRY-543
