1146699-58-2

Usage

Uses

Used in Pharmaceutical Research and Development:
(2R)-2-amino-5,5,5-trifluoro-pentanamide hydrochloride serves as a crucial component in the development of new drugs, leveraging its unique functional groups to create novel therapeutic agents. Its potential lies in its ability to be modified and combined with other molecules to form new pharmaceutical compounds with specific therapeutic targets.
Used in Biochemical and Pharmacological Studies:
As a research tool, (2R)-2-amino-5,5,5-trifluoro-pentanamide hydrochloride is employed in biochemical and pharmacological studies to investigate the mechanisms of drug action, interactions with biological systems, and potential side effects. Its unique structure allows researchers to probe the effects of specific functional groups on biological activity and pharmacokinetics.
Used in Drug Synthesis:
In the synthesis of drugs, (2R)-2-amino-5,5,5-trifluoro-pentanamide hydrochloride acts as a building block or intermediate, contributing to the formation of complex molecular structures with desired pharmacological properties. Its reactivity and stability make it a valuable component in the creation of new drug candidates.
Used in Medicinal Chemistry:
(2R)-2-amino-5,5,5-trifluoro-pentanamide hydrochloride is utilized in medicinal chemistry for the design and optimization of drug candidates. Its unique functional groups can be tailored to enhance the potency, selectivity, and pharmacokinetic properties of new therapeutic agents, making it an essential tool in the development of innovative medicines.

Upstream product

• 1146699-61-7 (R)-5,5,5-trifluoro-2-((R)-1-phenylethylamino)pentanamide hydrochloride 

Downstream Products

• 1146699-67-3 (R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide 

Relevant academic research and scientific papers

NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUNDS INCORPORATING DEUTERIUM AS INHIBITORS OF BETA AMYLOID PEPTIDE PRODUCTION

The present disclosure provides novel deuterated alpha-(N-sulfonamido)acetamide compounds, their pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease, head trauma, traumatic brain injury, and/or dementia pugilistica and/or other conditions associated with β-amyloid peptide.

Discovery and evaluation of BMS-708163, a potent, selective and orally bioavailable γ-secretase inhibitor

During the course of our research efforts to develop a potent and selective γ-secretase inhibitor for the treatment of Alzheimer's disease, we investigated a series of carboxamide-substituted sulfonamides. Optimization based on potency, Notch/amyloid-β precursor protein selectivity, and brain efficacy after oral dosing led to the discovery of 4 (BMS-708163). Compound 4 is a potent inhibitor of γ-secretase (Aβ40 IC50 = 0.30 nM), demonstrating a 193-fold selectivity against Notch. Oral administration of 4 significantly reduced Aβ40 levels for sustained periods in brain, plasma, and cerebrospinal fluid in rats and dogs.

Novel Alpha-(N-Sulfonamido)Acetamide Compound as an Inhibitor of Beta Amyloid Peptide Production

The present invention provides a novel alpha-(N-sulfonamido)acetamide compound, its pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease and other conditions associated with β-amyloid peptide.