114694-29-0Relevant academic research and scientific papers
Synthesis of Swinhoeisterol A, Dankasterone A and B, and Periconiastone A by Radical Framework Reconstruction
Duecker, Fenja L.,Heinze, Robert C.,Heretsch, Philipp
supporting information, p. 104 - 108 (2020/01/22)
A switchable radical framework reconstruction approach to structurally unique 13(14 → 8),14(8 → 7)diabeo-steroid swinhoeisterol A was developed. The conversion of an ergostane skeleton proceeded through the intermediacy of a 13(14 → 8)abeo-framework as pr
A volatile lactone of Hymenoscyphus pseudoalbidus, pathogen of European ash dieback, inhibits host germination
Citron, Christian A.,Junker, Corina,Schulz, Barbara,Dickschat, Jeroen S.
supporting information, p. 4346 - 4349 (2014/05/06)
The largely unknown secondary metabolism of the plant pathogenic fungus Hymenoscyphus pseudoalbidus was investigated by use of the CLSA method. A set of volatile lactones was identified by GC/MS. The lactones were synthesized and used in bioassays in which one of the compounds was found to be a strong germination inhibitor for ash seeds, causing necroses in the plant tissue. The largely unknown secondary metabolism of the plant pathogenic fungus Hymenoscyphus pseudoalbidus was investigated by use of the closed-loop stripping apparatus (CLSA) method. A set of volatile lactones was identified by GC/MS. The lactones were synthesized and used in bioassays in which one of the compounds was found to be a strong germination inhibitor for ash seeds.
Synthetic studies of the spirocyclic cyclohexene part of versipelostatin, a novel GRP78/Bip molecular chaperone downregulator
Sasaki, Shu,Samejima, Suguru,Uruga, Tomoki,Anzai, Kai,Nishi, Natsumi,Kawakita, Eriko,Takao, Ken-Ichi,Tadano, Kin-Ichi
, p. 147 - 154 (2013/08/25)
The spirocyclic part consisting of an -acylated tetronic acid and a multisubstituted cyclohexene embedded in versipelostatin, a novel GRP78/Bip molecular chaperone downregulator, has been synthesized in enantiomerically pure form. The asymmetric synthesis of the targeted spiro4.5-1-oxa-7-decen-2,4-dione derivative was characterized by (1) stereoselective allylation at the -carbon of methylmalonate diester, in which one carboxylic acid was esterified with a D-glucose-derived chiral template, (2) construction of the tetrasubstituted cyclohexenone substructure by high-yielding ring-closing metathesis and (3) stereoselective construction of the spirocyclic tetronic acid part starting from the cyclohexenone obtained as the ring-closing metathesis product.
Novel Convergent Synthesis of Side-Chain-Modified Analogues of 1α,25-Dihydroxycholecalciferol and 1α,25-Dihydroxyergocalciferol
Kutner, Andrzej,Perlman, Kato L.,Lago, Amparo,Sicinski, Rafal R.,Schnoes, Heinhrich K.,DeLuca, H. F.
, p. 3450 - 3457 (2007/10/02)
A novel synthetic strategy for the preparation of side-chain-modified analogues of 1α,25-dihydroxycholecalciferol and 1α,25-dihydroxyergocalciferol was developed as a part of the extensive synthetic search for vitamin D analogues of potential anticancer a
