1146955-52-3

Basic information

• Product Name: C₁₆H₁₅NO₃
• CAS NO: 1146955-52-3
• Molecular Weight: 269.3
• Mol File: 1146955-52-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₅NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₅NO₃(1146955-52-3)
• EPA Substance Registry System: C₁₆H₁₅NO₃(1146955-52-3)

Safety Data

• Hazardous Substances Data: 1146955-52-3(Hazardous Substances Data)

Upstream product

• 17791-62-7 N-(5-(t-butyl)-2-hydroxyphenyl)acetamide 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Regioselective syntheses of 2- and 4-formylpyrido[2,1-b]benzoxazoles

o-Acetaminophenols (2) reacted with Vilsmeier reagent under Meth-Cohn conditions to yield 2-formylpy-rido[2,l-6]benzoxazoles (5) unexpectedly besides the known compounds 2-(benzoxazol-2′-yl)-3-dimethylaminoacroleins (4). Refluxing 4 in acetic anhydride gave 4-formylpyrido[2,l-6]benzoxazoles (6), an isomer of 5. Both 5a and 6a were structurally characterized by X-ray crystallography. A mechanism for the formation of 5 involving sequential chlorination, dimerization, intramolecular elimination of HC1 to form the oxazole ring, formylation twice, and regioselective intramolecular nucleophilic cyclization to construct the pyridone ring is proposed.