1146971-51-8

Basic information

• Product Name: (S)-2-(methyl(prop-2-ynyl)amino)-3-phenylpropan-1-ol
• Synonyms: (S)-2-(methyl(prop-2-ynyl)amino)-3-phenylpropan-1-ol
• CAS NO: 1146971-51-8
• Molecular Weight: 203.284
• Mol File: 1146971-51-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-2-(methyl(prop-2-ynyl)amino)-3-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(methyl(prop-2-ynyl)amino)-3-phenylpropan-1-ol(1146971-51-8)
• EPA Substance Registry System: (S)-2-(methyl(prop-2-ynyl)amino)-3-phenylpropan-1-ol(1146971-51-8)

Safety Data

• Hazardous Substances Data: 1146971-51-8(Hazardous Substances Data)

Upstream product

• 84773-29-5 (S)-(+)-2-(N-methylamino)-3-phenylpropanol 
• 106-96-7 propargyl bromide 
• 2566-30-5 N-Methyl-L-phenylalanine 
• 50-00-0 formaldehyd 
• 3182-95-4 L-Phenylalaninol 

Downstream Products

• 1146971-64-3 4-bromobenzenesulfonic acid (S)-2-(methyl-prop-2-ynylamino)-3-phenylpropyl ester 
• 1146971-52-9 methanesulfonic acid (S)-2-(methyl-prop-2-ynyl-amino)-3-phenylpropyl ester 
• 1146972-99-7 N-(2-fluoro-3-phenylpropyl)-N-methylprop-2-yn-1-amine 
• 1146971-53-0 (S)-N-(1-fluoro-3-phenylpropan-2-yl)-N-methylprop-2-yn-1-amine 
• 1146972-97-5 (S)-N-(1-chloro-3-phenylpropan-2-yl)-N-methylprop-2-yn-1-amine 
• 1146972-98-6 N-(2-chloro-3-phenylpropyl)-N-methylprop-2-yn-1-amine 
• 1146971-54-1 N-[(2S)-1-[18F]fluoro-3-phenylpropan-2-yl]-N-methylprop-2-yn-1-amine 
• 1146973-00-3 N-(2-(18F)fluoro-3-phenylpropyl)-N-methylprop-2-yn-1-amine 
• 1253190-35-0 N-[(2R)-2-chloro-3-phenylpropyl]-N-methylprop-2-yn-1-amine 

Relevant articles and documents

Nucleophilic Fluorination and Radiofluorination via Aziridinium Intermediates: N-Substituent Influence, Unexpected Regioselectivity, and Differences between Fluorine-19 and Fluorine-18

The efficient dehydrofluorination and radiofluorination of N,N-disubstituted-β-aminoalcohols through an anchimeric-assisted mechanism was developed. An investigation into the influence of N-substituents on the ring opening of the aziridinium intermediate indicated differences in the isomeric ratio and the yields of fluorinated products obtained from N,N-disubstituted-phenylalaninol. This influence was substantial for 18F-radiofluorination, with yields varying from 0 to 71% at room temperature (RT). Although no significant effects were observed in the fluorine-19 chemistry when the reaction was heated to 90 °C, considerable changes appeared during radiofluorination. In the latter case, the radiochemical yields increased, and degradation of the 2-fluoro-propan-1-amine isomer (b) occurred, leading to a regiospecific reaction in the radiolabeling of [18F]-fluorodeprenyl. This method involving nucleophilic radiofluorination at RT was successfully applied to the radiolabeling of [18F]-2-fluoroethylamines in which the influence of the N-substituent was also observed.

NOVEL PRECURSOR MOLECULES FOR F-18 LABELLED PET TRACERS

This invention relates to novel compounds suitable as precursors for the preparation of certain F-18 labeled positron emission tomography (PET) tracers. Furthermore, the invention relates to the preparation of such precursor molecules and to the preparation of PET tracers by F-18 labeling of such precursors.