1147-23-5

Basic information

• Product Name: 5-Iodocytidine
• Synonyms: 1-BETA-D-RIBOFURANOSYL-5-IODOCYTOSINE;5-IODOCYTIDINE;1-D-Ribofuranosyl-5-iodocytosine;5-Iodo-D-cytidine;iodocytidine;5-IODOCYTIDINE,99+%;5-IC;4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one
• CAS NO: 1147-23-5
• Molecular Formula: C₉H₁₂IN₃O₅
• Molecular Weight: 369.11
• EINECS: 2017-001-1
• Product Categories: 5-FOA;Bases & Related Reagents;Nucleotides
• Mol File: 1147-23-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 565.461 °C at 760 mmHg
• Flash Point: 295.78 °C
• Appearance: White to Off-white/Crystalline or Powder
• Density: 2.527 g/cm³
• Vapor Pressure: 3.85E-15mmHg at 25°C
• Refractive Index: 1.85
• Storage Temp.: -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: 13.48±0.70(Predicted)
• Sensitive: Light Sensitive
• Stability: Light Sensitive
• CAS DataBase Reference: 5-Iodocytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodocytidine(1147-23-5)
• EPA Substance Registry System: 5-Iodocytidine(1147-23-5)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 1147-23-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

5-Iodocytidine is an intermediate for research in the field of nucleic acids and nucleic acid-protein interactions

InChI:InChI=1/C9H12IN3O5/c10-3-1-13(9(17)12-7(3)11)8-6(16)5(15)4(2-14)18-8/h1,4-6,8,14-16H,2H2,(H2,11,12,17)/t4-,5-,6-,8-/m1/s1

Upstream product

• 65-46-3 CYTIDINE 

Downstream Products

• 65-46-3 CYTIDINE 
• 83866-19-7 5-phenyl-cytidine 

Relevant articles and documents

A DNA-inspired synthetic ion channel based on G-C base pairing

A dinucleoside containing guanosine and cytidine at the end groups has been prepared using a modular one-pot azide-alkyne cycloaddition. Single channel analysis showed that this dinucleoside predominantly forms large channels with 2.9 nS conductance for the transport of potassium ions across a phospholipid bilayer. Transmission electron microscopy, atomic force microscopy, and circular dichroism spectroscopy studies reveal that this dinucleoside can spontaneously associate through Watson-Crick canonical H-bonding and π-π stacking to form stable supramolecular nanostructures. Most importantly, the ion channel activity of this G-C dinucleoside can be inhibited using the nucleobase cytosine.

Preparation method of novel nucleoside derivatives

The invention aims at providing a synthetic method of fluorescent nucleoside derivatives obtained by a reaction with 4-substituted phenylacetylene and 5-iodocytidine as raw materials in the catalysis of palladium dichloride/CuI. The method is characterize

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them.