1147097-16-2Relevant academic research and scientific papers
Novel cyclopentadienyl tricarbonyl 99mTc complexes containing 1-piperonylpiperazine moiety: Potential imaging probes for sigma-1 receptors
Wang, Xia,Li, Dan,Deuther-Conrad, Winnie,Lu, Jie,Xie, Ying,Jia, Bing,Cui, Mengchao,Steinbach, J?rg,Brust, Peter,Liu, Boli,Jia, Hongmei
, p. 7113 - 7125 (2014)
We report the design, synthesis, and evaluation of a series of novel cyclopentadienyl tricarbonyl 99mTc complexes as potent σ1 receptor radioligands. Rhenium compounds 3-(4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl)propylcarbonylcyclopentadienyl tricarbonyl rhenium (10a) and 4-(4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl) butylcarbonylcyclopentadienyl tricarbonyl rhenium (10b) possessed high in vitro affinity for σ1 receptors and moderate to high selectivity for σ2 receptors and the vesicular acetylcholine transporter. Biodistribution studies in mice demonstrated high initial brain uptake for corresponding 99mTc derivatives [99mTc]23 and [ 99mTc]24 of 2.94 and 2.13% injected dose (ID)/g, respectively, at 2 min postinjection. Pretreatment of haloperidol significantly reduced the radiotracer accumulation of [99mTc]23 or [99mTc]24 in the brain. Studies of the cellular uptake of [99mTc]23 in C6 and DU145 tumor cells demonstrated a reduction of accumulation by incubation with haloperidol, 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine (SA4503), or 1,3-di-o-tolyl-guanidine (DTG). Furthermore, blocking studies in C6 glioma-bearing mice confirmed the specific binding of [99mTc]23 to σ1 receptors in the tumor.
Aqueous syntheses of [(Cp-R)M(CO)3] type complexes (Cp = cyclopentadienyl, M = Mn, 99mTc, Re) with bioactive functionalities
Peindy N'Dongo,Liu,Can,Schmutz,Spingler,Alberto
, p. 981 - 987 (2009/05/27)
We describe reactions of [99mTc(H2O)3(CO)3)]+ (1) with Diels-Alder products of cyclopentadiene such as "Thiele's acid" (HCp-COOH)2 (2) and derivatives thereof in which the corresponding [(C
