114716-82-4

Upstream product

• 118993-51-4 (3aα,4α,5β,6β,7β,7aα)-4,5-bis(benzyloxy)-6,7-epoxyhexahydro-2,2-dimethylbenzo-1,3-dioxole 
• 125291-06-7 (3aα,4β,5α,6β,7α,7aα)-6,7-bis(benzyloxy)-5-fluorohexahydro-2,2-dimethylbenzo-1,3(2H)-dioxol-4-ol 
• 130633-23-7 (3aα,4α,5β,6α,7β,7aα)-6-fluorohexahydro-2,2-dimethylbenzo-1,3(2H)-dioxol-4,5,7-triol 

Downstream Products

• 181138-33-0 ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3R,5S,6R,7R,8R,9R)-8-(tert-butyl-dimethyl-silanyloxy)-9-fluoro-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester 

Relevant academic research and scientific papers

Synthesis of (±)-4-deoxy-4-fluoro-myo-inositol

4-Deoxy-4-fluoro-myo-inositol was prepared by means of DAST with reaction of configuration due to the assistance of a neighbouring benzyl ester.

MICROBIAL OXIDATION IN SYNTHESIS: PREPARATION OF MYO-INOSITOL PHOSPHATES AND RELATED CYCLITOL DERIVATIVES FROM BENZENE.

Pseudomonas putida oxidation of benzene affords cis-3,5-cyclohexadiene-1,2-diol (2) which is used as a novel precursor for the synthesis of D- and L-myo-inositol 1,4,5-triphosphates, (-)-(1) and (+)-(1).The versatility of this approach to functionalised cyclitols is illustrated in the synthesis of myo-inositol 1-phosphate (19), 6-deoxy, 6-deoxy-6-fluoro, and 6-deoxy-6-methyl myo-inositols (31), (37) and (43), and their 1,4,5-trisphosphate derivatives (33), (39) and (45).