114720-06-8

Basic information

• Product Name: 7-ethyl-5-hydroxytryptophol
• Synonyms: 7-ethyl-5-hydroxytryptophol
• CAS NO: 114720-06-8
• Molecular Weight: 205.257
• Mol File: 114720-06-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-ethyl-5-hydroxytryptophol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-ethyl-5-hydroxytryptophol(114720-06-8)
• EPA Substance Registry System: 7-ethyl-5-hydroxytryptophol(114720-06-8)

Safety Data

• Hazardous Substances Data: 114720-06-8(Hazardous Substances Data)

Upstream product

• 114737-75-6 2,3-dihydro-7-ethyl-1H-indole-3-ethanol 

Downstream Products

• 101901-06-8 6-hydroxyetodolac 

Relevant articles and documents

Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites

The syntheses of five metabolites of the antiinflammatory drug etodolac (1,8-diethyl-1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acid) are described, viz. 6-hydroxyetodolac, N-methyletodolac, 4-ureidoetodolac, 8-(1'-hydroxy)etodolac, and 4-oxoetodolac. These syntheses were used to confirm the identities of the metabolites. The metabolites themselves, as well as the previously reported metabolite 7-hydroxyetodolac, were tested in a rat adjuvant edema model and in vitro for their capacity to block prostaglandin production in chondrocyte cells. All either were inactive or possessed only marginal activity. The isolation of N-methyletodolac and 4-oxoetodolac from human and rat urine, respectively, is also described.