114724-98-0Relevant articles and documents
Dithiolane-Isocyanate Imminium Methylides: A Rapid Stereoselective Entry into γ-Lactams
Fishwick, Colin W. G.,Foster, Richard J.,Carr, Robin E.
, p. 9409 - 9412 (1995)
Methods have been developed for the generation and trapping of dithiolane-isocyanate imminium methylides which are a new type of azomethine methylide-derived 1,3-dipole.These species add efficiently and stereoselectively to electron deficient olefins yielding novel dithiolane-protected γ-lactams which can be efficiently deprotected to yield the corresponding lactam systems.
Cyclic imine nitro-Mannich/lactamization cascades: A direct stereoselective synthesis of multicyclic piperidinone derivatives
Jakubec, Pavol,Helliwell, Madeleine,Dixon, Darren J.
supporting information; experimental part, p. 4267 - 4270 (2009/05/30)
(Chemical Equation Presented) An efficient nitro-Mannich/lactamization cascade of γ-nitro esters with cyclic imines for the preparation of architecturally complex multicyclic piperidinone ring-containing structures has been developed. The reaction is broad in scope and stereoselective and may be coupled to an enantioselective nitroolefin Michael addition reaction as part of a highly enantio- and diastereoselective multicomponent process.
QUINOLINE COMPOUNDS AND METHODS OF USE
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Page/Page column 154, (2008/06/13)
Compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof, are useful for inhibiting receptor tyrosine kinases and for treating hyperproliferative disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [ Formula I]
