1147347-29-2

Upstream product

• 1253121-13-9 (2R,4S)-4-amino-4-phenylbutan-2-ol 
• 530-62-1 1,1'-carbonyldiimidazole 
• 1147347-28-1 (2R,4S)-4-(tert-butoxycarbonylamino)-4-phenylbutan-2-ol 

Relevant academic research and scientific papers

Enantioselective synthesis of syn - And anti -1,3-aminoalcohols via β-aminoketones and subsequent reduction/dynamic kinetic asymmetric transformation

β-Aminoketones obtained from imines in an organocatalytic Mannich reaction were transformed to enantio- and diastereomerically pure 1,3-aminoalcohols with two stereogenic centers via a combined reduction/dynamic kinetic asymmetric transformation. Both syn and anti diastereomers were obtained in high yield, dr, and ee.

1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV: Part 2

Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.