1147422-12-5 Usage
Chemical structure
A piperidine ring with a tert-butyl and a methyl group attached to the 1st and 3rd carbons, respectively, and an azetidine ring attached to the 4th carbon. The compound also has two carboxylate groups attached to the 1st and 3rd carbons.
Type of compound
A selective antagonist for histamine H2 receptors
Uses in research
Studying the effects of histamine on physiological and pathological processes
Medical uses
Treating peptic ulcers and other gastrointestinal disorders, reducing the production of gastric acid, treating allergic reactions and inflammatory conditions, and potential use in the treatment of schizophrenia and other central nervous system disorders.
Mechanism of action
Tisotidine works by blocking the action of histamine on H2 receptors in the stomach, which reduces the production of gastric acid. It may also have anti-inflammatory and immunomodulatory effects, which may be useful in the treatment of allergic reactions and inflammatory conditions.
Versatility
Tisotidine is a versatile compound with potential therapeutic applications in various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 1147422-12-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,7,4,2 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1147422-12:
(9*1)+(8*1)+(7*4)+(6*7)+(5*4)+(4*2)+(3*2)+(2*1)+(1*2)=125
125 % 10 = 5
So 1147422-12-5 is a valid CAS Registry Number.
1147422-12-5Relevant articles and documents
THIENOPYRIMIDIENE DERIVATIVES AS PI3K INHIBITORS
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Page/Page column 84, (2009/05/28)
Thienopyrimidines of formula (I) wherein W and R1 to R4 are as defined in the claims, and the pharmaceutically acceptable salts thereof are inhibitors of PI3K and are selective for the p110δ isoform, which is a class Ia PI3 kinase, over both other class Ia and class Ib kinases. The compounds may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
